Mongolic phonology and the Qinghai-Gansu languages

The peripheral Mongolic languages of the Qinghai-Gansu area in China comprise Eastern Yugur (Shira Yugur) and the Shirongol languages. The latter can be subdivided in a Monguor branch, consisting of Mongghul and Mangghuer, and a Baoanic branch, consisting of Baoan, Kangjia, and Dongxiang (Santa). The internal taxonomy of the Qinghai-Gansu languages will be discussed in a separate section. The Qinghai-Gansu languages are increasingly well-described. They have also been the subject of studies in language contact, mostly in the context of the Amdo or Qinghai-Gansu Sprachbund. This study will approach the phonology of Qinghai-Gansu Mongolic from a comparative historical viewpoint. It provides an overview of the phonological developments of the Qinghai-Gansu languages, comparing them to the reconstructed ancestral language. At the same time it will investigate the archaic features that can be found in these languages, in order to improve the reconstructions of individual Mongolic lexemes. The book ends with a comparative supplement of about 1350 reconstructed Common Mongolic items, accompanied by the modern forms they are based on and, where necessary, arguments for the chosen reconstruction.LEI Universiteit LeidenLanguage Use in Past and Presen

Roofline-aware DVFS for GPUs

Graphics processing units (GPUs) are becoming increasingly popular for compute workloads, mainly because of their large number of processing elements and high-bandwidth to off-chip memory. The roofline model captures the ratio between the two (the compute-memory ratio), an important architectural parameter. This work proposes to change the compute-memory ratio dynamically, scaling the voltage and frequency (DVFS) of 1) memory for compute-intensive workloads and 2) processing elements for memory-intensive workloads. The result is an adaptive roofline-aware GPU that increases energy efficiency (up to 58%) while maintaining performance

A study of the potential of locality-aware thread scheduling for GPUs

Programming models such as CUDA and OpenCL allow the programmer to specify the independence of threads, effectively removing ordering constraints. Still, parallel architectures such as the graphics processing unit (GPU) do not exploit the potential of data-locality enabled by this independence. Therefore, programmers are required to manually perform data-locality optimisations such as memory coalescing or loop tiling. This work makes a case for locality-aware thread scheduling: re-ordering threads automatically for better locality to improve the programmability of multi-threaded processors. In particular, we analyse the potential of locality-aware thread scheduling for GPUs, considering among others cache performance, memory coalescing and bank locality. This work does not present an implementation of a locality-aware thread scheduler, but rather introduces the concept and identifies the potential. We conclude that non-optimised programs have the potential to achieve good cache and memory utilisation when using a smarter thread scheduler. A case-study of a naive matrix multiplication shows for example a 87% performance increase, leading to an IPC of 457 on a 512-core GPU

Facial-muscle weakness, speech disorders and dysphagia are common in patients with classic infantile Pompe disease treated with enzyme therapy

Classic infantile Pompe disease is an inherited generalized glycogen storage disorder caused by deficiency of lysosomal acid α-glucosidase. If left untreated, patients die before one year of age. Although enzyme-replacement therapy (ERT) has significantly prolonged lifespan, it has also revealed new aspects of the disease. For up to 11 years, we investigated the frequency and consequences of facial-muscle weakness, speech disorders and dysphagia in long-term survivors. Sequential photographs were used to determine the timing and severity of facial-muscle weakness. Using standardized articulation tests and fibreoptic endoscopic evaluation of swallowing, we investigated speech and swallowing function in a subset of patients. This study included 11 patients with classic infantile Pompe disease. Median age at the start of ERT was 2.4 months (range 0.1-8.3 months), and median age at the end of the study was 4.3 years (range 7.7 months −12.2 years). All patients developed facial-muscle weakness before the age of 15 months. Speech was studied in four patients. Articulation was disordered, with hypernasal resonance and reduced speech intelligibility in all four. Swallowing function was studied in six patients, the most important findings being ineffective swallowing with residues of food (5/6), penetration or aspiration (3/6), and reduced pharyngeal and/or laryngeal sensibility (2/6). We conclude that facial-muscle weakness, speech disorders and dysphagia are common in long-term survivors receiving ERT for classic infantile Pompe disease. To improve speech and reduce the risk for aspiration, early treatment by a speech therapist and regular swallowing assessments are recommended

Resource Quantity Affects Benthic Microbial Community Structure and Growth Efficiency in a Temperate Intertidal Mudflat

Estuaries cover <1% of marine habitats, but the carbon dioxide (CO2) effluxes from these net heterotrophic systems contribute significantly to the global carbon cycle. Anthropogenic eutrophication of estuarine waterways increases the supply of labile substrates to the underlying sediments. How such changes affect the form and functioning of the resident microbial communities remains unclear. We employed a carbon-13 pulse-chase experiment to investigate how a temperate estuarine benthic microbial community at 6.5°C responded to additions of marine diatom-derived organic carbon equivalent to 4.16, 41.60 and 416.00 mmol C m−2. The quantities of carbon mineralized and incorporated into bacterial biomass both increased significantly, albeit differentially, with resource supply. This resulted in bacterial growth efficiency increasing from 0.40±0.02 to 0.55±0.04 as substrates became more available. The proportions of diatom-derived carbon incorporated into individual microbial membrane fatty acids also varied with resource supply. Future increases in labile organic substrate supply have the potential to increase both the proportion of organic carbon being retained within the benthic compartment of estuaries and also the absolute quantity of CO2 outgassing from these environments

German evidence-based guidelines for the treatment of Psoriasis vulgaris (short version)

Psoriasis vulgaris is a common and chronic inflammatory skin disease which has the potential to significantly reduce the quality of life in severely affected patients. The incidence of psoriasis in Western industrialized countries ranges from 1.5 to 2%. Despite the large variety of treatment options available, patient surveys have revealed insufficient satisfaction with the efficacy of available treatments and a high rate of medication non-compliance. To optimize the treatment of psoriasis in Germany, the Deutsche Dermatologische Gesellschaft and the Berufsverband Deutscher Dermatologen (BVDD) have initiated a project to develop evidence-based guidelines for the management of psoriasis. The guidelines focus on induction therapy in cases of mild, moderate, and severe plaque-type psoriasis in adults. The short version of the guidelines reported here consist of a series of therapeutic recommendations that are based on a systematic literature search and subsequent discussion with experts in the field; they have been approved by a team of dermatology experts. In addition to the therapeutic recommendations provided in this short version, the full version of the guidelines includes information on contraindications, adverse events, drug interactions, practicality, and costs as well as detailed information on how best to apply the treatments described (for full version, please see Nast et al., JDDG, Suppl 2:S1–S126, 2006; or http://www.psoriasis-leitlinie.de)

First Cold Powering Test of REBCO Roebel Wound Coil for the EuCARD2 Future Magnet Development Project

EuCARD-2 is a project partly supported by FP7-European Commission aiming at exploring accelerator magnet technology for 20 T dipole operating field. The EuCARD-2 collaboration is liaising with similar programs for high field magnets in the USA and Japan. EuCARD-2 focuses, through the work-package 10 'Future magnets,' on the development of a 10 kA-class superconducting, high current density cable suitable for accelerator magnets, for a 5 T stand-alone dipole of 40 mm bore and about 1 m length. After standalone testing, the magnet will possibly be inserted in a large bore background dipole, to be tested at a peak field up to 18 T. This paper starts by reporting on a few of the highlight simulations that demonstrate the progress made in predicting: dynamic current distribution and influence on field quality, complex quench propagation between tapes, and minimum quench energy in the multitape cable. The multiphysics output importantly helps predicting quench signals and guides the development of the novel early detection systems. Knowing current position within individual tapes of each cable we present stress distribution throughout the coils. We report on the development of the mechanical component and assembly processes selected for Feather-M2 the 5 T EuCARD2 magnet. We describe the CERN variable temperature flowing helium cold gas test system. We describe the parallel integration of the FPGA early quench detection system, using pickup coils and temperature sensors, alongside the standard CERN magnet quench detection system using voltage taps. Finally we report on the first cold tests of the REBCO 10 kA class Roebel subscale coil named Feather-M0